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Standardized Extract Shiitake Mushroom Extract,Lentinus edodes Extract

Country/Region china
Company Gentcare Natural Ingredients, Inc.
Categories Other Mushrooms & Truffles
Telephone +86-731-8228 7663, +86 139 0748 7460
ICP License Issued by the Chinese Ministry
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    Standardized Extract Shiitake Mushroom Extract,Lentinus edodes Extract

     Standardized Extract,Herbal Extract >> Shiitake Mushroom Extract,Lentinus edodes Extract
       Product Name:
     Shiitake Mushroom Extract,Lentinus edodes Extract
       Latin Name:
     Lentinula edodes
       Plant part used:
     Whole Mushroom(Fruiting Bodies)
       Active Ingredient:
     Polysaccharides (as Beta-Glucan: Letinan)
     6%, 10%, 15%, 25% Polysaccriarides, 4:1
       Test Method:
       Case No:
       Main Function:
     Stimulate Immune System and Anti-viral (including anti-HIV and anti-HSV-1)

    Brief Introduction
    --- Lentinus edodes, Xianggu (Chinese: ), Shiitake(Japanese: )
    Letinan (Beta-Glucan)
    Chemical Name:
    Beta-Glucan, -D-glucopyranosyl-(16)-[-D-glucopyranosyl-(13)-[-D-glucopyranosyl-(16)]--D-glucopyranosyl-(13)--D-glucopyranosyl-(13)-D-glucopyranosyl-(13)]--D-glucopyranose
    Molecular Formula: C42H72O36
    Mol. Wt.: 1152.99948
    Molecular Structure::
    The Shiitake (Lentinula edodes) is an edible mushroom native to East Asia, which is cultivated and consumed in many Asian countries, as well as being dried and exported to many countries around the world. It is a feature of many Asian cuisines including Chinese, Japanese, Korean and Thai. In the East, the Shiitake mushroom has long been considered a delicacy as well as a medicinal mushroom.
    The Shiitake Mushroom Extract used in dietary supplements is derived from the whole mushroom (the fruiting bodies of Lentinula fungi).

    Shiitake mushroom is a popular culinary mushroom used in cuisine throughout the world. It contains a high concentration of Lentinan, which is a beta-glucan isolated from the Shiitake mushroom fruiting bodies. Research has demonstrated the Shiitake mushroom:
     Stimulates the immune system
     Contains a cholesterol lowering compound known as eritadenine.
     Possesses anti-bacterial properties
     Possesses anti-viral properties (including anti-HIV and anti-HSV-1) (contains a proteinase inhibitor)
     Reduces platelet aggregation

    Beta-glucan and the immune system
    Beta-glucans are known as "biological response modifiers" because of their ability to activate the immune system. Immunologists at the University of Louisville, discovered that a receptor on the surface of innate immune cells called Complement Receptor 3 (CR3 or CD11b/CD18) is responsible for binding to beta-glucans, allowing the immune cells to recognize them as "non-self." However, it should be noted that the activity of beta-glucans is different from some pharmaceutical drugs which have the ability to over-stimulate the immune system. Pharmaceutical drugs have the potential to push the immune system to over-stimulation, and hence are contraindicated in individuals with autoimmune diseases, allergies, or yeast infections. Beta-glucans seem to make the immune system work better without becoming overactive. In addition to enhancing the activity of the immune system, beta-glucans also reportedly lower elevated levels of LDL cholesterol, aid in wound healing, help prevent infections, and have potential as an adjuvant in the treatment of cancer.
    Research of Lentinan shows: An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937. An in vivo experiment on mice, revealed lentinan is orally active (since clinical use of the drug is administered through an IV). Limited clinical studies of cancer patients have associated lentinan with a higher survival rate, higher quality of life, and lower re-occurrence of cancer.

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