Benzocaine hydrochloride salt is the hydrochloride salt form of the
local anesthetic benzocaine, with the same pharmacological effects
of benzocaine and weaker effect of anesthesia than procaine. Local
absorption is slow with lasting effect. It cannot be used for
anesthesia as a result of not being dissolved in water. It can be
used for pain relief and anti-itch. Benzocaine hydrochloride is
usually made into powder or oil paste and used to heal wounds,
ulcers, burns, skin abrasions and hemorrhoids.
Benzocaine is also called parathesin, Sinai sisin. Separated from
water is colorless or white orthorhombic crystals or crystalline
powder, precipitated from ether to square crystal. No smell.
Bitter. Relative molecular mass 165.19. Melting point 92 degrees
Celsius. The boiling point of 310 DEG C, 183 to 184 C (1.87 x
103Pa). Insoluble in water, soluble in ethanol, ether and
chloroform, also soluble in almond oil, olive oil and dilute acid.
Stable in the air.
From p-nitrotoluene, in sulfuric acid, using sodium dichromate
oxidation, formation of p-nitrobenzoic acid, esterification with
ethanol, after the completion of the reaction, separation, the
ethyl p-nitrobenzoate in acetic acid solution, with iron powder in
85 ~ 95 DEG C reduction, available benzocain crude. After the
separation, water washing, and then recrystallization in ethanol.
Benzocaine is an anaesthetic drug, mostly used for application
direct to the skin.
Benzocaine HCl is a salt modification of benzocaine, formed when
benzocaine is complexed with hydrochloric acid. Often, drug salts
have enhanced properties compared with the parent compound.
For example, benzocaine hydrochloride is more water soluble than
benzocaine, making it more appropriate for oral administration.
- There are quite a few different uses for Benzocaine, these include:
- As an ingredient in cough syrups
- To treat cold sores
- To treat toothache
- To treat irritation from dentures
- To treat earache
- As a surgical local anesthetic
- In condoms used to delay ejaculation
- To tranquilize Fish
Benzocaine is the main local anesthesia for pain experienced in the
gums, teeth and also for relieving sore throat. Apart from treating
oral irritations it is also used to treat otic pain i.e. pain
experienced in the ear. Moreover it is incorporated in certain
surgical procedures as a local anesthesia.
It comes prepared in a variety of ways such as gel, aerosol and
paste for otic purposes. Benzocaine spray used to relieve pain in
the throat and lining of the mouth is not applicable to children
under the age of two unless prescribed by a doctor. The spray is
used on patients fitting dentures on their gums to relieve pain.
It is important to note that in such cases the spray should not be
a long term solution to pain caused by poorly fitted dentures.