Articaine hydrochloride Local Anaesthetic For Pain Reliever
Product Name:Articaine hydrochloride
Appearance: White crystalline powder
articaine is a dental local anesthetic. it is the most widely used local anesthetic in a
number of european countries and is available in many countries around the world
articaine hydrochloride,articaine is an intermediate-potency,
short-acting amide local anesthetic with a fast metabolism due to
an ester group in its structure. it is effective with local
infiltration or peripheral nerve block in dentistry, when
administered as a spinal, epidural, ocular, or regional nerve
block, or when injected intravenously for regional anesthesia.
articaine hydrochloride, in comparative trials, its clinical
effects were not generally significantly different from those of
other short-acting local anesthetics like lidocaine, prilocaine,
and chloroprocaine, and there is no conclusive evidence
demonstrating above-average neurotoxicity. articaine proved to be
suitable and safe for procedures requiring a short duration of
action in which a fast onset of anesthesia is desired, eg, dental
procedures and ambulatory spinal anesthesia, in normal and in
- Articaine is a local anaesthetic that has been approved overseas
for several years. Like other amide anaesthetics, articaine blocks
nerve conduction when it is infiltrated around a nerve. This action
is prolonged by combining the drug with a vasoconstrictor .
The combination of articaine can be used for local or regional
anaesthesia for dental procedures. Anaesthesia begins within six
minutes and lasts for an hour. The half-life of articaine is
approximately 1.8 hours. It is metabolised and then mainly excreted
in the urine.
- articaine hydrochloride, articaine blocks nerve conduction by
reversibly binding to the α-subunit of the voltage-gated sodium
channels within the inner cavity of the nerve, similar to other
local anesthetics. binding of articaine to the sodium channel
reduces sodium influx so that the threshold potential will not be
reached and impulse conduction stops. the blocking action of
articaine on the sodium channel is state dependent: it has the
highest affinity for the open state, an intermediate affinity for
the inactivated state, and the lowest affinity for the resting
- articaine hydrochloride, the degree of neuronal block is affected
by the diameter of the nerve. larger-diameter fibers
(touch/pressure/ motor) require higher concentrations of local
anesthetic compared with small myelinated fibers (pain
afferents).articaine is lipid soluble, highly protein-bound (94%),
and has a dissociation constant (pka) of 7.8. articaine is an
intermediate-potency, short-acting local anesthetic with a fast
onset of action.
|product name||articaine hydrochloride|
|production date||2016/09/27||shelf life||2018/09/26|
|standard adopted||ep 7|
|description||white or almost white crystalline powder||white crystalline powder|
|solubility||freely soluble in water and in alcohol||complies|
|appearance of solution||solution should be clear||complies|
|related substance||impurity a ≤0.2%; any other impurity ≤0.1%; total of other
not detected; 0.08%; 0.26%
|loss on drying||< 0.5%||0.09%|
|residue on ignition||≤0.1%||0.09%|
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