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Good Quality Pharmaceutical Intermediate Raw Powder Sertraline Hydrochloride / Sertraline HCL For Anti-Depression

Categories Pharmaceutical Raw Materials
Brand Name: TINGYI
Model Number: 79559-97-0
Certification: GMP, SGS , ISO 9001:2008 , KOSHER
Place of Origin: China
MOQ: Negotiation
Price: Contact Us
Payment Terms: Western Union, MoneyGram, Bank Transfer, Bitcoin
Supply Ability: 100 KG/Month
Delivery Time: Within 7 Work Days
Packaging Details: Stealth And Discreet Packaging
Product Name: Sertraline Hydrochloride
Other Name: Sertraline HCL
Appearance: White Powder
CAS No.: 79559-97-0
Purity: 99% Min
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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    Good Quality Pharmaceutical Intermediate Raw Powder Sertraline Hydrochloride / Sertraline HCL For Anti-Depression


    Good Quality Pharmaceutical Intermediate Raw Powder Sertraline Hydrochloride / Sertraline HCL For Anti-Depression


    Sertraline Hydrochloride


    CAS:79559-97-0

    MF:C17H18Cl3N

    MW:342.69

    EINECS:200-659-6

    Synonyms:(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE;(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE HYDROCHLORIDE;(1S,4S)-1-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-(METHYLAMINO)NAPHTHALENE HYDROCHLORIDE;N-(4(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)NAPHTHALIDENE) METHANAMINE;SERTRALINE HCL FORM I;SERTRALINE HCL FORM II;SERTRALINE HYDROCHLORIDE;SERTRALINE MANDELATE

    Properties

    Melting point:246-249°C

    alpha D23 +37.9° (c = 2 in methanol)

    Density 1.37

    Flash point:9℃

    storage temp. Desiccate at RT

    solubility DMSO: ~26 mg/mL

    form solid

    pkapKa (water): 9.48 ± 0.04; pKa (methanol:water, 40:60 v/v): 8.6; pKa (ethanol:water, 1:1 v/v) 8.5(at 25℃)

    color white

    Merck 8467

    Stability:Store in Freezer

    Safety Information

    Symbol(GHS)


    Abstract


    Sertraline is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline is primarily prescribed for major depressive disorder in adult outpatients as well as obsessive-compulsive disorder, panic disorder, and social anxiety disorder, in both adults and children.

    Differences with other newer antidepressants are subtle and mostly confined to side effects. It has a similar tolerability profile to other SSRIs, with the types of adverse events usually including diarrhea, nausea, and sexual dysfunction. The incidence of diarrhea was higher with sertraline-especially when prescribed at higher doses-in comparison to other SSRIs.

    Sertraline is used for a number of conditions including: major depression, obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social anxiety disorder.It has also been used for premature ejaculation and vascular headaches but evidence of the effectiveness in treating those conditions is not robust.


    COA


    ItemRequirementsTest Results
    DescriptionA white or almost white crystalline powderwhite crystalline powder
    Identification
    IR spectrumConcordant with the working referenceComplies
    Discrimination chlorideForward reactionComplies
    HPLCConcordant with the working referenceComplies
    Related Substances
    Total impurities≤1.0%0.6%
    Individual impurities≤0.50%0.28%
    Sulphated ash≤0.1 %0.04%
    Optical rotation+36.0 ~ 42.0+39.2
    SolubilityInsoluble in dimethyl sulfoxide and sparingly soluble in methanolComplies
    Melting point242 ~ 248ºC243ºC ~ 245ºC
    Loss on drying≤ 0.5 %0.13%
    Heavy metals≤20ppm<10ppm
    Assay [C18 ODS colum]98.5 % ~101.5 %(on dried basis)99.7%
    Assay [with chiral colum]≥97.0 %97.8 %
    ConclusionMeets the Requirements

    Application


    Treat male premature ejaculation and erectile dysfunction.


    Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used.


    However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.


    How Can I Take ?


    According to the provisions of the doctor, taking sertraline. Follow all directions in your prescription label. Your doctor sometimes changes your dose to ensure you get the best results. Do not use the drug in a larger or smaller amount or longer than the recommended drug.

    Sertraline can be with or without food. Take medications at the same time every day.

    The liquid (oral concentrate) form of sertraline must be diluted first. To ensure that you are receiving the correct dose, use the provided drug dropper to measure the fluid. Mix 4 ounces (half a cup) of water, ginger, lemon / lime soda, lemonade or orange juice. Do not use any other liquid to dilute the drug. Stir the mixture and drink immediately. To ensure that you are able to get the entire dose, add a little water to the same glass, gently rotate and drink immediately.

    This medicine may cause you to conduct a false positive drug screening test. If you provide urine samples for drug screening, please inform the laboratory staff that you are taking sertraline.

    Symptoms can be improved before it may take 4 weeks. Follow the instructions to continue using the medication and tell the doctor whether your symptoms are improving.

    Do not suddenly stop using sertraline, otherwise there may be unpleasant withdrawal symptoms. Ask your doctor how to safely stop using sertraline.

    Store at room temperature to avoid moisture and heat.


    More info


    1. Lead Time: Within 12hours after you payment


    2. Delivery Time: 3-7 working days


    3. Packing: Very discreet or as your requirement


    4. Shipping: DHL / TNT / UPS / HKEMS / FEDEX / ETC.


    5. Tracking number: The tracking number will give to you after goods send out at first time.


    6. After-sales service: 24/7 online for you to solve problems.

    Welcome to order our products. It's Ida, hope to cooperate with you, be your reliable supplier and build a long friendly relationship with you.


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