2g - 5g Ophthalmic Medication Cream Ointment Chloramphenicol Eye
Ointment For Babies
Product : Chloramphenicol 1% w/w Eye Ointment
Specification : 1%, 2g, 3g, 5g
Standard : BP, USP
Packing : one tube per box
Chloramphenicol is a broad spectrum antibiotic for the treatment of
bacterial conjunctivitis caused by chloramphenicol susceptible
Consideration should be given to official guidance on the
appropriate use of antibacterial agents. Escherichia coli,
Haemophilus influenzae, Staphylococcus aureus, Streptococcus
haemolyticus, Morax-Axenfeld, Klebsiella/Enterobacter species and
Chloramphenicol is indicated in adults and children.
Posology and method of administration
Adults, children and infants: The recommended dosage for adults,
children and infants of all age groups is a small amount of the
ointment to be applied to the affected eye every 3 hours or more
frequently if required. Treatment should be continued for 48 hours
after the eye appears normal.
Elderly: As for adults. Chloramphenicol has been used successfully
at normal dosages in elderly patients. The pattern and incidence of
adverse effects does not appear to differ from younger adults.
Dosage adjustment may be necessary in newborn infants because of
reduced systemic elimination due to immature metabolism and the
risk of dose-related adverse effects. The maximum duration of
treatment is 10-14 days.
Method of administration
Topical administration to the eye only.
The ointment must not be administered to:
• Patients who have a history of hypersensitivity to
chloramphenicol or to any of the excipients.
• Patients who have experienced bone marrow suppression during
previous exposure to chloramphenicol.
• Patients with a known personal or family history of blood
dyscrasias including aplastic anaemia.
Special warnings and precautions for use
Chloramphenicol is absorbed systemically from the eye and systemic
toxicity has been reported.
Bone marrow hypoplasia, including aplastic anaemia and death, has
been reported following topical use of chloramphenicol. Whilst the
hazard is a rare one, it should be borne in mind when assessing the
benefits expected from the use of the compound.
If the eye ointment is to be used on a long-term or intermittent
basis, it may be advisable to perform a routine blood profile
before therapy and at appropriate intervals thereafter to detect
any haemopoietic abnormalities.
In severe bacterial conjunctivitis and in cases where infection is
not confined to the conjunctivae, the topical use of
chloramphenicol should be supplemented by appropriate systemic
Chloramphenicol does not provide coverage against Pseudomonas spp.
or serratia marcescens.
The use of topical chloramphenicol may occasionally result in
overgrowth of non-susceptible organisms including fungi. If any new
infection appears during treatment, the antibiotic should be
discontinued and appropriate treatment given.
It is recommended that all types of contact lenses be avoided
during ocular infections.
Do not use for more than 5 days without consulting a doctor.
Medical advice should be sought if there is no improvement in the
condition after 2 days or if symptoms worsen at any time.
Patients should be referred to their doctor if any of the following
• Disturbed vision;
• Severe pain within the eye;
• Eye inflammation associated with a rash on the scalp or face;
• The eye looks cloudy;
• The pupil looks unusual;
• Suspected foreign body in the eye.
Patients should also be referred to their doctor if any of the
following in his/her medical history apply:
• Previous conjunctivitis in the recent past;
• Dry eye syndrome;
• Eye surgery or laser treatment in the last 6 months;
• Eye injury;
• Current use of other eye drops or eye ointment;
If you wear contact lenses, seek advice either from your contact
lens practitioner (optician, optometrist) or doctor before you use
this product. You should not wear your contact lenses during the
course of treatment. If you wear soft contact lenses do not start
wearing them for at least 24 hours after you have finished using
the eye ointment.
Chloramphenicol Side Effects
Along with its needed effects, a medicine may cause some unwanted
effects. Although not all of these side effects may occur, if they
do occur they may need medical attention.
Check with your doctor immediately if any of the following side
Rare - may also occur weeks or months after you stop using
sore throat and fever
unusual bleeding or bruising
unusual tiredness or weakness
Check with your doctor as soon as possible if any of the following
side effects occur:
Itching, redness, skin rash, swelling, or other sign of irritation
not present before use of chloramphenicol
Some side effects may occur that usually do not need medical
attention. These side effects may go away during treatment as your
body adjusts to the medicine. Also, your health care professional
may be able to tell you about ways to prevent or reduce some of
these side effects. Check with your health care professional if any
of the following side effects continue or are bothersome or if you
have any questions about them:
Burning or stinging
After application, eye ointments may be expected to cause your
vision to blur for a few minutes.
Other side effects not listed may also occur in some patients. If
you notice any other effects, check with your healthcare