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Local Anesthetic Tetracaine HCl CAS 136-47-0 Tetracaine For Pain Reliever

Categories Pharmaceutical Raw Materials
Brand Name: XinRunde
Model Number: 136-47-0
Certification: GMP
Place of Origin: China(Mainland)
MOQ: 5g
Price: Negotiable
Payment Terms: T/T bank, Western Union, Bitcoin
Supply Ability: 10 000 KG /month
Delivery Time: 5-7 days after received your payments
Packaging Details: 1-2 kg / aluminum foil bag, 25kg/ drum, as required
Color: White
Alias: Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; Amethocaine hydrochloride
Appearance: White Powder
Usage: mucosa anesthetic
Type: Pharmaceutical Raw Materials
Delivery: DHL, UPS, Fed Ex, etc
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    Local Anesthetic Tetracaine HCl CAS 136-47-0 Tetracaine For Pain Reliever

    COA of 136-40-3 from.pdf


    Local Anesthetic Tetracaine HCl CAS 136-47-0 Tetracaine for Pain Reliever



    Quick Details:


    Product name: Tetracaine HCl

    Synonyms:Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; Amethocaine hydrochloride

    CAS : 136-47-0

    Molecular formula: C15H25ClN2O2
    Molecular weight: 300.82
    EINECS: 205-248-5
    Appearance: Fine white crystalline and odorless powder
    Melting point: 145~150 degree
    Assay: 99%
    Grade: Pharmaceutical Grade
    Usage: Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.



    Product Description:

    1. Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.


    2. Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5‱ (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.


    3. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt cannulations.



    Specifications:



    Items

    QUALITY STANDARDS

    RESULTS

    Description

    White or almost white crystalline powder

    White crystalline powder

    Solubility

    Matching with the working standard

    Complies


    Identification

    A.By IR, To match with working standard

    Complies

    B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80ºC for 2h,melts at about 131ºC


    Complies

    C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops

    Complies

    D. Solution S gives reaction of chlorides.

    Complies

    PH

    4.5~6.5

    5.78

    Residual Solvents

    Conform to standard

    Complies

    Claruty

    Solution should be clear

    Complies

    Related Substances

    Conform to standard

    Complies

    Heavy metals

    ≤10ppm

    <10ppm

    Loss on drying

    ≤1.0%

    0.87%

    Resiue on ignition

    ≤0.1%

    0.05%

    Melting range

    148ºC

    147.5ºC~150.8ºC

    Assay(*)

    99%~101.0%

    100.40%

    Conclusion

    The Sample Complies With Specification of EP8



    Applications:

    1.Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.


    2.In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.





    Advantages:


    Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

    1 . Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.

    2 . Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.

    3 . Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate

    4 . Warm after-sale service Any of your question would be solved for the first as soon as possible.


    Keywords: Local Anesthetic / Tetracaine HCl / CAS 136-47-0


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